The use of mid-fi eld infrared spectroscopy in combination with chemometric algorithms for the identifi cation of cephalosporin antibiotics in the form of injectable powders is demonstrated. III generation cephalosporins have been selected as objects of the study: ceftriaxone, ceftazidime, cefotaxime, which are widely used in pharmaceutical practice. IR spectra of the medical preparations have been recorded using an FT-801 Fourier transform IR spectrometer with an attenuated total refl ection (ATR) attachment.