Izvestiya of Saratov University.
Chemistry. Biology. Ecology
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)

4-гидроксикумарин

Synthesis and biological activity of compounds based on 4-hydroxycoumarin

Currently, the synthesis of oxygen-containing heterocyclic compounds containing a fused benzene ring system with a pyrone cycle, represented by 4-hydroxycoumarin (4-hydroxy-2H-chromen-2-one), is of great importance due to their broad spectrum of biological activity. We found it interesting to conduct reactions of 1,5-dicarbonyl compounds based on 4-hydroxycoumarin with N-nucleophiles, both from a fundamental point of view and from the perspective of the practical application of the resulting products.

Синтез и биологическая активность соединений на основе 4-гидроксикумарина

В настоящее время синтез кислородсодержащих гетероциклических соединений, содержащих конденсированную систему бензольного ядра с пироновым циклом, представителем которых является 4-гидроксикумарин (4-гидрокси-2H-хромен-2-он), является очень важным, в связи с их широким спектром биологической активности. Нам представилось интересным проведение реакций 1,5-дикарбонильных соединений на основе 4-гидроксикумарина с N-нуклеофилами, как с фундаментальной точки зрения, так и с позиции практического применения полученных продуктов.

Selective mycotoxines sorbent based on molecular imprinted polyaniline structures

The constant increase in contamination of agricultural products with mycotoxins makes it urgent to develop new methods for their sorption, isolation, and determination. Molecular imprinting is a promising method for recognizing and isolating target molecules based on specifi c sorption mechanism. The work considers the possibility of obtaining and practical use of mycotoxin–specifi c selective sorbents based on imprinted polyaniline structures using a structural analogue of the mycotoxin zearalenone – 4-hydroxycoumarin.