антимикробная активность

We developed various options of biologically active agents based on the core–shell structure technology. They were obtained by layering biocompatible polymer on the surface of the carriers. As a core, we used a heterocyclic compound comprising of enamine and flavonoid nanoaggregates. As a shell, we used polу azolidinе аmmonium modified by iodine hydrate-ions. Our results implied a significant increase in antimicrobial activity of the preparations developed by us.

The complex estimation of toxicity of the polymer compounds – poly azolidin ammonium, modified hydrate ions of iodine, which has high antimicrobial activity was held. It is established that working concentrations of parent drug and its variants with different hydrate ions of iodine content do not cause death of biotestobjects of Daphnia magna Straus.

The antimicrobial activity of the nanoparticles of silver stabilized by various natural and synthetic polymeric compounds concerning reference and clinical strains of Staphylococcus aureus is studied. It is established that the greatest effectiveness was displayed by the silver nanoparticles stabilized by polyvinyl alcohol, carboxymethylcellulose and poliazolidinammonium, the modified iodine hydrate ions. The low sensitivity of the studied strains to action of the nanoparticles stabilized by an oleate of S.