Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


ctxA

Evaluation of ctxA gene expression of Vibrio cholerae strain 569B in the production of cholera vaccine

Cultivation of production strains of Vibrio cholerae is one of the most important stages in the production of cholera bivalent chemical vaccines. In the production of immunobiological preparations, it is necessary to use producer strains with stable properties that persist in a number of generations. The aim of this study was to evaluate the expression of the ctxA gene using molecular genetic methods of the V. cholerae 569B producing strain.