Izvestiya of Saratov University.

Chemistry. Biology. Ecology

ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


For citation:

Mazhukina О. А., Fedotova О. V. Morden Aspects in Chemistry of Condensed 2H-chromen-2-ones. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2010, vol. 10, iss. 2, pp. 3-7. DOI: 10.18500/1816-9775-2010-10-2-3-7

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Full text:
(downloads: 30)
Language: 
Russian
Heading: 
Article type: 
Article
UDC: 
547.822.1+544.18

Morden Aspects in Chemistry of Condensed 2H-chromen-2-ones

Autors: 
Mazhukina О. А., Saratov State University
Fedotova О. V., Saratov State University
Abstract: 

The bromination of condensed chromen-2-ones is carried out. The influence of medium on the reaction occurrence has been studied. In the acidic acid solution aromatization of the 4H-pyrane fragment or hydrogen atom substitution at the tertiary carbon atom takes place. In chloroform, addi­ tion of bromine by the double bond occurs. Mixture of tetrachloromethane and propanol-2 promotes the intermolecular dehydration with the formation of ether bond.

Reference: 
 

 

1. 

Парфёнов Э.Смирнов Л. Гетероциклические биоантиоксиданты // ХГС. 1992. №3. С.329-334.

2. 

Kostova I. Synthetic and natural coumarins as cytotoxic agents // Curr. Med. Chem. - Anti-Cancer Agents. 2005. Vol.5. P.29-46.

3. 

Евстигнеева Р.П.Воков И.М.Чудинова В.В. Витамин Е как универсальный антиоксидант и стабилизатор биологических мембран // Биол. мембраны. 1998. Т. 15, №12. С.119-136.  EDN: MPBJLB

4. 

Никонов Г.К. Фурокумарин как группа веществ растительного происхождения с противораковой активностью // Тр. ВНИИ лекарственных и ароматических растений, М., 1959. №11. С.180-201.

5. 

Yuan Н, Parrill L. QSAR studies of HIV-1 integrase inhibition // Bioorg. and Med. Chem. 2002. Vol.10. P.4169-4183.

6. 

Miltra A.Aparna D.Karchaudhuri N. Synthesis of coumarin in search of better nonpeptide HIV protease inhibitors // J. Indian Chem. Soc. 1988. Vol.75. P.667-671.

7. 

He Zhao, Neamati N., Hong H. Coumarin-based inhibitors of HIV integrase ill. Med. Chem. 1997. Vol.40. P. 242-249.

8. 

Feuer G., Keilen J,A., Kovacs К. Suppression of 7,12-dimetylbtyzantracens-induced breat careinoma by coumarin in the rat// Oncoly. 1976. Vol.33. P.35-39.

9. 

Riboulleau J., Deschamps-Vallet C, Molho D. Preparation et heterocyclisation reductrice de divers o-hydroxybenzylidene-3 dioxo-2,4 chromannes // Bull. Soc. Chim. Fran. 1970.¹8.P.3138-3144.

10. 

Hagiwara H.Fujimoto N.Suzuki T. Synthesis of methylenbis(4-hydroxy-2-pyrone) or methylenbis(4-hydroxycoumarin) derivatives by organic solid state reaction // Heterocycles.2000. Vol.53, №3. P.549-552.

Received: 
07.12.2009
Accepted: 
24.01.2010
Published: 
03.03.2010
Short text (in English):
(downloads: 17)