The introduction of the (trifluoro)acetyl moiety into different heterocycles allows one to vary their physicochemical properties, change the nature and magnitude of biological activity, and also to carry out further chemical transformations. At the same time, modern methods of organic chemistry are aimed, inter alia, at increasing the efficiency of known and widely used chemical reactions and the possibility of directing along other paths when conducting syntheses under conditions, which are different from the classical ones.