Changes in the Permeability of the Blood-Brain Barrier in the Development of Alzheimer’s Disease in Mice

In our study on mice with an injection model of Alzheimer’s disease (AD), beta-amyloid detection in the brain tissue was evaluated using immunohistochemistry and confocal analysis. An accumulation of toxic protein was shown in different areas of the brain, predominantly in the cortex and in the hippocamp (place of beta-amyloid injection). Neurofunctional tests were conducted to confirm the development of AD.

Morphogenesis and Reproductive Ability Monocarpic Escape Hosta sieboldiana (Hook.) Engl. (Hostaceae) in the Conditions of the Novosibirsk Region

The results of studying the morphogenesis of monocarpic escape during the seasonal development of Hosta sieboldiana are presented. It is shown that organ-forming processes of generative organs occur in the spring-summer vegetation of the shoot. Generative shoot is formed at 75–76 of days to flowering. Established, that the cone of increase of the escape differentiates intrarenal II to VIII stages of organogenesis. The flowers are laid in the acropolis direction. Duration of flowering was 25–38 days, fruiting 29–30 days. Real seed productivity is 3–4 times lower than potential.

Genetic Polymorphism in Populations of Hieracium × robustum (Asteraceae) as Result of the Hallabrottet Aulacidea hieracii (Hymenoptera: Cynipidae) Influence

Based on Inter Simple Sequence Repeats (ISSR), we examined polymorphism in populations of Hieracium × robustum (Asteraceae) – the host of gall-making Aulacidea hieracii (Hymenoptera, Cynipidae). In each population, we studied H. × robustum specimens with and without stem galls induced by gall wasps. It was revealed that individual gallfree plants have half as much ISSR fragments as plants contaminated by galls. In agarose gel, ISSR fragments of the former have clear-cut patterns while patterns of gall-contaminated plants are shapeless.

Ontogenetic Structure and Population Status of the Relict Species of Hedysarum gmelinii Ledeb. in the Cis-Urals Republic of Bashkortostan

The results of studying the ontogenetic structure of coenopopulations of the relict species Hedysarum gmelinii Ledeb. in the Bashkortostan of Republic are presented. The investigated cenopopulations growing on slopes of different exposure, with a slope of 35°, is the main type of vegetation – Helictotrichon desertorum–Stipa korshinskyi petrophyte steppe, anthropogenic load is low or medium. The overall density of the coenopopulations of H. gmelinii varies from 1,7 to 12,2 ind./m2, an effective density from 1,5 to 4,6 ind./m2.

Modern Cadastre of Vectors and Other Reservoirs of Tularemia Microbe Found in Tularemia Foci of Different Types, Situated in the Territory of Russia

At the present stage of the studies only Ixodidae ticks can be classed by the types of foci, being the main blood-sucking vectors of the tularemia agent. Other blood-sucking arthropods, considering the species abundance and wide-spread occurrence and certain habitat versatility, can be tularemia vectors in several or even in all types of foci. These are the following: primarily, gamaside and argasid ticks, as well as bloodsucking insects.

The Coefficient of Replenishment for the Commercial Stock of Catfish from the Release of Its Juvenile by Weighing Batch of 2 Grams in the Reservoirs of the Volga-Caspian Fishery Basin

The practical value of the coefficient of commercial replenishment of fish stocks, due to the variety of its use in different areas of fisheries research, design work, restoration activities, and management decisions was highlighted. For many species of fish there is no information on the indicator under consideration. Catfish, one of the valuable commercial species, is included in this category.

Assessment of the Impact of the Nanoparticles of Silver Stabilized by Polymeric Compounds on Survival of Strains of Staphylococcus aureus

The antimicrobial activity of the nanoparticles of silver stabilized by various natural and synthetic polymeric compounds concerning reference and clinical strains of Staphylococcus aureus is studied. It is established that the greatest effectiveness was displayed by the silver nanoparticles stabilized by polyvinyl alcohol, carboxymethylcellulose and poliazolidinammonium, the modified iodine hydrate ions. The low sensitivity of the studied strains to action of the nanoparticles stabilized by an oleate of S.

Application of New Instrumental Methods for Evaluation of the Functional State of Cells of Francisella Tularensis in a Stressful Environment

The structure of the cell surface reflects the functional state of the bacterium as a whole. The presence of specific features of cells affects the biophysical characteristics of their surface: charge, free energy and hydrophobicity. The interaction of bacteria with biomolecules and particles is also related to these surface characteristics. The aim of our work was to study the function of F. tularensis 15 NIIEG cells under cultivation under stress using electro-optical (EO) monitoring.

Antimicrobial Photodynamic Effects Using Coatings Based on Metal Nanoparticles (Ag, Au)

The combined effect of coatings based on nanoparticles of metals Ag, Au, ultraviolet (365 nm, UVR) and infrared (808 nm, IRR) radiation on Staphylococcus aureus 209 P was studied. Decrease in numbers was shown by 2% in the case of silver coatings and by 8% in the case of gold coatings after 1 h incubation. However, exposure of the IRR to bacterial suspensions caused the death of 43% of the population after 5 min, 86% of the population after 30 min.

Changes in Blood-Brain Barrier Permeability under the Influence of Loud Sound

The development of methods of drug delivery to the brain is one of the priorities of the therapy of most cerebral diseases. There are more than 70 technologies to overcome the blood-brain barrier (BBB), but many of them are not widely used in daily clinical practice, as they lead to negative consequences. Here we propose a new method of overcoming the BBB using loud sound (110 dB, 370 Hz, duration – 2 hours).