We studied the gender particularities in renal hypertension development and the dynamics of cardiovascular effects of immobilization stress in normotensive and hypertensive male and female rats. Also, we investigated the cardiovascular sensitivity to adrenaline and propranolol in normotensive and hypertensive males and females. We revealed the stronger sympathetic control of cardiovascular activity in females vs. males that may be partly responsible for the greater cardiovascular stress resistance in females compared with males.