statins

Statins, key drugs for the prevention of cardiovascular disease, are represented by a number of structurally diverse compounds requiring reliable identifi cation methods to ensure their quality control. This study, for the fi rst time, provides a comprehensive comparative analysis of all commercially signifi cant statins (lovastatin, simvastatin, pravastatin, fl uvastatin, atorvastatin, rosuvastatin, and pitavastatin) using complementary spectral methods: UV, FTIR (ATR), ¹H NMR spectroscopy, and mass spectrometry.

The chromatographic behavior of atorvastatin, rosuvastatin and simvastatin in the presence of the main modifi ers of the mobile phase: elution strength and buff er solution, has been studied by means of the reverse-phase high-performance liquid chromatography (HPLC) method. Optimal modifi cation conditions have been found and their application for the determination of statins under study in the pharmaceutical preparations Atorvastatin-OBL, Liprimar and Tulip has been shown. The Sr value is 0.03. The relative determination error does not exceed 7%.