Izvestiya of Saratov University.
ISSN 1816-9775 (Print)
ISSN 2541-8971 (Online)


смартфон

Non-destructive control of tablet forms of cefuroxime by near-infrared spectroscopy and digital colorometry methods

Non-destructive control of cefuroxime in tablet medicines without opening the blister pack by measuring the intensity of diff use refl ectance of infrared radiation has been proposed. Near-infrared Fourier transform spectroscopy and digital color spectroscopy using a smartphone and a 3D-printed device have been applied. The data set has been processed by principal component methods, hierarchical cluster analysis and partial least squares regression.

Неразрушающий контроль таблетированных форм цефуроксима методами ближней ИК-спектроскопии и цифровой цветометрии

Предложен неразрушающий контроль цефуроксима в таблетированных лекарственных средствах без вскрытия блистерной упаковки по измерению интенсивности диффузного отражения ИК-излучения. Применяли методы ближней ИК-спектроскопии с преобразованием Фурье и цифровой цветометрии с использованием смартфона и напечатанного на 3D-принтере устройства. Обработку массива данных проводили методами главных компонент, иерархического кластерного анализа и частичной регрессии наименьших квадратов.

Smartphone use in solid-phase fl uorimetric determination of some polypeptide antibiotics in medicinal preparations

The analysis of semi-products at diff erent stages of production and fi nished medicinal products is an integral part of an eff ective quality assurance system for pharmaceutical production. The traditional methods used in the pharmaceutical fi eld, such as capillary electrophoresis, gas and liquid chromatography, are quite versatile and eff ective. However, they are distinguished by the high cost of instrumentation and component materials, the need to use high-purity solvents, the lack of mobility and the possibility of in situ studies.