Cite this article as:

Yadrova A. A., Shafigulin R. V., Bulanova A. V. The Investigation of Benzimidazoles’ Sorption on Modified Silicagels and Hypercrosslinked Polystyrene by HPLC. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2020, vol. 20, iss. 3, pp. 275-283. DOI:

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).

The Investigation of Benzimidazoles’ Sorption on Modified Silicagels and Hypercrosslinked Polystyrene by HPLC

Тип статьи для РИНЦ: 
RAR научная статья

The production of good-quality, effective and harmless pharmaceutical products and import substitution of drugs are of top priority for the pharmaceutical industry. Benzimidazole and its derivatives are active substances of many drugs due to the wide range of their pharmacological activity. In the article under consideration the sorption of the newly synthesized benzimidazole’s derivatives from liquids media was studied. Reverse phase high performance liquid chromatography (RP HPLC) is the most appropriate method used for the analysis of biologically active substances, particularly drugs. The thermodynamic characteristics of benzimidazole sorption and its newly synthesized 14 derivatives from water-acetonitrile solutions on hexadecyl and octadecyl silicagels, as well as on hypercrosslinked polystyrene (HCL), were calculated. The enthalpies and entropy components of sorption were calculated. The effect of the composition of the organic modifier on thermodynamic characteristics of benzimidazole sorption was studied.

  1. Strategiya razvitiya farmatsevticheskoy promyshlennosti Rossiyskoy Federatsii na period do 2030 goda v sootvetstvii s ukazom Prezidenta Rossiyskoy Federatsii ot 7 maya 2018 goda «O natsional’nykh tselyakh i strategicheskikh zadachakh razvitiya Rossiyskoy Federatsii na period do 2024 goda» [Strategy of development of pharmaceutical industry of the Russian Federation for the period till 2030 in accordance with the decree of the President of the Russian Federation from May 7, 2018 “On the national goals and strategic objectives development of the Russian Federation for the period up to 2024”]. State Automated Information System “Management”, Public discussion of projects. [Electronic resource]. Available at: (accessed 2 September 2019).
  2. Gazizova A. F., Kurbatov E. R., Rudakova I. P., Kurbatova A. A., Zvereva E. V., Bobyleva A. A., Fokin Y. V. Search for biologically active compounds in a series of hydrasons of NH-benzoyl-5-iodoantranylic acid. Biomedicine, 2018, no. 3, pp. 35–44 (in Russian).
  3. Kodonidi I. P., Novikov O. O., Kuleshova S. A., Rjabukhin J. I., Shatokhin S. S., Ivchenko A. V., Kodonidi M. I., Zhilina O. M. Synthesis of new N-hydroxyphenyl and tolyl derivatives of pyrimidine-4(1H) – one with antiinfl ammatory activity. Pharmacy & Pharmacology, 2017, no. 5 (6), pp. 556–567 (in Russian). DOI:
  4. Matyushin A. A., Nesterova О. V., Malanova O. A., Popkov V. A. The prospects for pharmaceutical use of herbal raw material containing alkylamides. Medical & Pharmaceutical Journal “Pulse”, 2017, vol. 19, no. 1, pp. 123–128 (in Russian). DOI:
  5. Borovskiy B. V., Koval N. O., Kompantsev V. A., Kodonidi Ya. P. Studying the pure indicators of new biologically active compound PMFI-195. Bulletin of Science and Education, 2019, no. 1 (55), pt. 2, pp. 82–85 (in Russian).
  6. Saidov N. D., Malkova T. L., Bulgakova E. A. The study of the extraction of monomachine from aqueous solutions. Innovation Science, 2019, no. 7–8, pp. 124–125 (in Russian).
  7. Bondarev A. V., Zhilyakova E. T. Use of sorption processes in the technology of drug delivery systems. Pharmacy & Pharmacology, 2019, vol. 7, no. 1, pp. 4–12 (in Russian). D0I:
  8. Volokitina D. S., Ozerov A. A., Lazaryan D. S., Volokitin S. V. Development and validation of the spectrophotometric technique for quantitative analysis of a new biologically active compound, a derivative of-4 (3H)-one quinazoline. Journal of VolgSMU, 2017, iss. 2 (62), pp. 35–38 (in Russian). DOI:
  9. Trineeva O. V., Halahakun A. J., Slivkin A. I. Development and validation of spectrophotometric quantitative determination of terpene-indole alkaloids (for example, vincristine sulfate and vinblastine sulfate). Scientific Bulletins of Belgorod State University. Ser. Medicine. Pharmacia, 2018, vol. 41, no. 4, pp. 687–702 (in Russian). DOI:
  10. Kazakevich Y., Lobrutto R. HPLC for Pharmaceutical Scientists. New Jersey, John Wiley, 2007. 1135 p.
  11. Wöll S., Schiller S., Bachran Ch., Lee Kim Swee, Scherlie R. Pentaglycine lipid derivates – rp-HPLC analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems. International Journal of Pharmaceutics, 2018, vol. 547, iss. 1-2, pp. 602–610. DOI:
  12. Popov A. Yu., Blinnikova Z. K., Tsyurupa M. P., Davankov V. A. Synthesis and adsorption prop erties of restricted access sorbents based on hypercrosslinked polystyrene. Sorption and Chromatography Processes, 2017, vol. 17, no. 2, pp. 183–190 (in Russian). DOI:
  13. Smirnova L. A., Ozerov A. A., Suchkov E. A., Riabuha A. F., Kuznetsov K. A. Specifi c of sample preparation for HPLC method of quantitative determination of slightly soluble compounds. Volgograd Journal of Medical Resaarch, 2013, vol. 2, pp. 9–15 (in Russian).
  14. Morozov A. S., Kopitsyna M. N., Bessonov I. V., Karelina N. V., Nuzhdina A. V., Sarkisov I. Y., Pavlova L. A., Tsyurupa M. P., Blinnikova Z. K., Davankov V. A. A selective sorbent for removing bacterial endotoxins from blood. Russian Journal of Physical Chemistry A, 2016, vol. 90, no. 12, pp. 2465–2470 (in Russian). DOI:
  15. Zherdev V. P., Kolyvanov G. B., Litvin A. A., Bochkov P. O., Gribakina O. G., Shevchenko R. V., Tarasyuk A. V., Gudasheva T. A. Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats. Pharmacokinetics and Pharmacodynamics, 2019, no. 1, pp. 37–43 (in Russian). DOI:
  16. Yadrova A. A., Shafi gulin R. V., Bulanova A. V., Golov A. A., Belousova Z. P. Studying the Sorption of Certain Benzimidazoles on Octadecyl. Silica Gel from Water-Acetonitrile Solutions via Liquid Chromatography. Russian Journal of Physical Chemistry A, 2018, vol. 92, no. 8, pp. 1572–1582 (in Russian). DOI:
  17. Pietrogrande M. C., Benvenuti A., Dondi F. Temperature effect on HPLC retention of pcbs on porous graphitic carbon. Chromatographia, 2000, vol. 51, iss. 3-4, pp. 193–198. DOI:
Short text (in English): 
Full text (in Russian):