Cite this article as:

Semyachkina-Glushkovskaya O. V., Gekalyuk A. S., Sindeeva O. A., Abdurashitov A. S. Role of Sulfonylurea Receptor in the Development of Stress-induced Hemorrhagic Cerebral Infarction in Newborn Rats. Izvestiya of Saratov University. New series. Series: Chemistry. Biology. Ecology, 2015, vol. 15, iss. 2, pp. 80-85.


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UDC: 
612.14
Language: 
Russian

Role of Sulfonylurea Receptor in the Development of Stress-induced Hemorrhagic Cerebral Infarction in Newborn Rats

Abstract

In this article, we develop a model of hemorrhagic infarct of brain in neonatal rats. The results of histological analysis showed that on the next day after exposure to stress sound (120 dB) for 2 hours, there are small focal subcortical hemorrhage, the brain edema, hypoxia and accumulation of blood area of in macro- and microcirculation. Speckle imaging of cerebral circulation revealed hyperperfusion of brain tissue with increase size of the cerebral veins in newborn rats with stress-induced intracranial hemorrhages. These pathological changes in cerebral blood flow accompanied by high expression of sulfonylurea receptors in the brain tissue that is not detected in normal. These results allowed us to conclude that the sulfonylurea receptors may play an important role in the development of hemor- rhagic cerebral infarction in the first days after birth, which is also shown by other researchers on adult rats.

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