Cite this article as:

Laksaeva E. A., Davydov V. V., Kyarimov I. A., Kukhtenkova E. A., Arushanova V. V., Zlobina E. A. Polysaccharidebased Biological Activity of Extracts Isolated from Fruits of Crataegus Monogyna of Varying Degrees of Maturity. Izvestiya of Saratov University. New series. Series: Chemistry. Biology. Ecology, 2019, vol. 19, iss. 2, pp. 216-222. DOI: https://doi.org/10.18500/1816-9775-2019-19-2-216-222


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615.322:547.458
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Russian

Polysaccharidebased Biological Activity of Extracts Isolated from Fruits of Crataegus Monogyna of Varying Degrees of Maturity

Abstract

The fruits of midland hawthorn (Cratae gusoxyacantha L.), as well as leaves and flowers have a complex composition. A water-soluble polysaccharide complex, flavonoids and saponins, and other biologically active compounds were revealed in them. Consequently, preparations made from the vegetable material of hawthorn have a high biological activity. A liquid extract of fruits and a tincture of hawthorn flowers, are widely used in medicine. These drugs are used for cardiovascular diseases, have a sedative and hypotensive effect. The role of separate groups of substances contained in the fruits of hawthorn in the formation of such a marked biological activity is of interest. One of such groups is polysaccharides. Recent studies have shown that plant polysaccharides have a wide range of biological activities and are used in medicine and veterinary. In this study, new data have been revealed, indicating that fruits extracted from midland hawthorn (Cratae gusoxyacantha L.) of various degrees of ripeness in case of enteral administration in animals strengthen erythropoiesis, increasing the amount of erythrocytes and of hemoglobin in the blood of experimental animals (rats), increase their physical performance and resistance to hypobaric hypoxic hypoxia. At the same time, the output of polysaccharide from unripe (green) fruits is 1.74 times higher than that of ripe ones. The article contains data that the biological activity of the (PCЕ) extracted from unripe hawthorn fruits in a number of indices is higher than the biological activity of the PCЕ extracted from ripe hawthorn fruits.

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