Cite this article as:

Agranovich I. M., Khorovodov A. P., Mamedova A. T., Shnitenkova A. A., Shimanova V. E., Novolokin N. A., Vashenko T. S., Kanevsky M. V., Galitskaya A. A., Konnova S. А., Borisova E. G., Semyachkina-Glushkovskaya O. V. Photodynamic Diagnostics of Stomach Cancer. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2019, vol. 19, iss. 1, pp. 50-57. DOI: https://doi.org/10.18500/1816-9775-2019-19-1-50-57


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Photodynamic Diagnostics of Stomach Cancer

Abstract

Cancer of the stomach is the main cause of death among cancer diseases of the gastrointestinal tract. This is due to the late diagnosis. This study was aimed at developing new methods for diagnosis of gastric cancer using a photosensitizer 5-ALK / PIXIX. The experiments were carried out on white non-native rats with an average mass of 250 grams. The animals were divided into 2 groups: control and experimental (stress + nitrosamine diet). The results of the studies, averaged for this type of tissue, clearly show significant differences between normal, precancerous and malignant changes in the stomach tissues of rats. The fluorescence from malignant neoplasms in the organ was maximal at 635 nm, where the protoporphyrin emission maximum is located due to the high accumulation of photosensitizer in the tissues. The most important result was the fact that precancerous changes (atrophic gastritis), which subsequently were confirmed histologically, were also detected in the process of photodiagnostics. The intensity of fluorescence in this case occupied an intermediate value between the norm and malignant lesions of the stomach.

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