Cite this article as:

Postnov D. E. Laser-induced Vasomotor Responses on Chorioallantoic Membrane. Izvestiya of Saratov University. New series. Series: Chemistry. Biology. Ecology, 2018, vol. 18, iss. 1, pp. 71-?. DOI: https://doi.org/10.18500/1816-9775-2018-18-1-71-78


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Laser-induced Vasomotor Responses on Chorioallantoic Membrane

Abstract

The strength and the specific featu res of the vasomotor responses provide important information about the healthy state of the blood vessel, since it s contraction or dilation is caused by the activation or relaxation of vascular smooth muscle cells of the vascular wall and appears to be a universal response to the a number of physiological regulatory pathways, including humoral and neurogenic ones. While the methods for testing the isolated vessel fragment ex vivo are well developed and widely used in research, a similar problem with respect to a functioning microcirculatory network is much more complicated and largely unresolved. In this paper, we investigate the possibilities of a new method of to test a fragment of an arterial vessel within the network. Namely, we study the vasomotor reactions of a single arterial vessel of a chick embryo chorioallantoic membrane in situ induced by laser irradiation. Our results show that the reaction type (dilatation or constriction) depends essentially on the wavelength of the laser radiation. In a number of cases, a biphasic response is detected, when initial dilatation upon repeated exposures is replaced by constriction. The developed technique is proposed to be used as a nondestructive and non-contact experimental technique for the studies of microcirculatory network functions.

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