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Sumina E. G., Reshetnikova I. S., Uglanova V. Z., Yurasov N. A. Chromatographical Analysis of Meldonium with Preliminary Concentration by Solid-Phase Extraction on Magnetite Nanoparticles. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2020, vol. 20, iss. 4, pp. 378-386. DOI:

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Chromatographical Analysis of Meldonium with Preliminary Concentration by Solid-Phase Extraction on Magnetite Nanoparticles

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RAR научная статья

A comprehensive method for meldonium analysis, based on a combination of magnetic solid-phase concentration of the analyte on magnetite nanoparticles modified with cetylammonium bromide (CTAB) cations and its subsequent analysis by thin-layer chromatography (TLC) were developed in the process of study. The influence of a number of factors on meldonium sorption was studied, namely: pH, sorbent mass, sorption and mixing times; optimal extraction conditions were determined. It was found that quantitative sorption proceeded in 20 min with a meldonium extraction degree of 88%. Ethanol was found to be an eluent to desorb the analyte by 95%. The calibration dependences plotted with and without concentration of meldonium were compared. It was established that the use of concentration on two mg of CTAB-modified nanomagnetite reduces the lower limit of the analyzed contents of meldonium in 25 ml of solution by 5 times.

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