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Esma S. A., Abdurashitov A. S., Namykin A. A., Shirokov A. A., Lykova E. Y., Sarantseva E. I., Iskra T. D., Vodovozova E. L., Khorovodov A. P., Terskov A. V., Mamedova A. T., Agranovich I. M., Klimova M. M., Semyachkina-Glushkovskaya O. V. Changes in Blood-Brain Barrier Permeability under the Influence of Loud Sound. Izvestiya of Saratov University. Chemistry. Biology. Ecology, 2019, vol. 19, iss. 3, pp. 312-322. DOI:

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Changes in Blood-Brain Barrier Permeability under the Influence of Loud Sound


The development of methods of drug delivery to the brain is one of the priorities of the therapy of most cerebral diseases. There are more than 70 technologies to overcome the blood-brain barrier (BBB), but many of them are not widely used in daily clinical practice, as they lead to negative consequences. Here we propose a new method of overcoming the BBB using loud sound (110 dB, 370 Hz, duration – 2 hours). Independent results on mice obtained in several experimental groups clearly demonstrate that sound significantly increases the permeability of BBB to high-molecular substances, as well as to liposomes (100 nm) simulating the delivery to the brain of solutes, proteins and materials with nanocarriers. Sound-induced BBB opening is safe (according to the assessment of the absence of perivascular edema and apoptosis) and reversible (opening / closing of BBB after 1 h/4 h after exposure to sound, respectively) due to compensatory changes in cerebral blood flow. Thus, sound as a natural factor is a new and promising easily feasible method for the successful delivery of drugs to the brain.

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