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Глинская Е. В., Нечаева О. В., Лунева И. О., Аль-Баяти Б. М. ANTIBIOTIC SUSCEPTIBILITY OF PATHOGENS IN URINARY TRACT INFECTIONS IN COMMUNITY. Izv. Saratov Univ. (N. S.), Ser. Math. Mech. Inform., 2015, vol. 15, iss. 4, pp. 63-? DOI: 10.18500/1816-9775-2015-15-4-63-66




This study was done to evaluate the bacterial profile and antibiotic susceptibility pattern of urinary tract infections (UTIs) microbial causative agents. For proper identification of causative microbial agents, mid– stream urine (MSU) samples were taken from 325 patients suspected to have UTI. These specimens were cultured and subjected to appropriate biochemical tests. Our results revealed that 200 urine samples showed positive cultures. The most prevalence isolates were Escherichia coli with frequency rate of 55.5%, followed by Klebsiella spp. (14%), Enterobacter spp. (11.5%), Proteus spp. (10%), and Pseudomonas spp. (6%). However, Morganella morganii and Acinetobacter baumannii showed similar frequency rate of 1.5%, respectively. All isolates were sensitive to imipenem and amikacin (100%). The majority of isolates were sensitive to nitrofurantion (71%), tobramycin (64%) and ciprofloxacin (58.5%). Whereas, high level resistance was seen against ampicillin (92%), augmentin (86%), trimethoprim – sulfamethoxazole (83%).


1. Foxman B., Barlow R., D’arcy H. UTI: Self-reported incidence and associated costs // Ann. Epidemiol. 2000. Vol. 10. P. 509‒515.

2. Mandelle G. L., Benntt J. E., Dolin R. Principles and practice of infectious diseases. 5th ed. Philadelphia : Churchill Livingstone, 2005. P. 881‒882.

3. Barret S. P., Savage M. A., Rebec M. P., Guyot A. Antibiotic sensitivity of bacteria associated with community acquired UTI in Britain // J. Antimicrob. Chemother. 1999. Vol. 44. P. 359‒365.

4. Karbwsky J. A., Jones M. E., Thornsberry C., Friedland I. R., Sahm D. F. Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the US from 1998-2001 // J. Antimicrob. Agents and Chemother. 2003. Vol. 47. P. 1672‒1680.

5. Nicolle L. E. Uncomplicated UTI in adult including uncomplicated pyelonephritis // Urol. Clin. Nor. Amer. 2008. Vol. 35, № 1. P. 1‒12.

6. Dromigny J. A., Nabeth P., Juergens B. A., PerrierGros-Claude J. D. Risk factors for antibiotic-resistance Escherichia coli UTI in Dakar, Senegal // J. Antimicrob. Chemother. 2005. Vol. 56. P. 236‒239.

7. Bronsema D. A., Adams J. R., Pallares R. Secular trends in rates and etiology of nosocomial UTIs at a university hospital // J. Urol. 1993. Vol. 150. P. 414‒416.

8. Zalamanovici T. A., Green H., Paul M., Yaphe J., Leibovici L. Antimicrobial agents for treating uncomplicated UTIin women // Cochrane Database System. Rev. 2010. Vol. 10, № 10.

9. Bachelier C. D., Bernslein J. M. Urinary Tract Infections // Med. Clin. North. Amer. 1997. Vol. 81. P. 719‒729.

10. Annabelle T., Dytan M. D., Jennifer A., Chua M. D. Surveillance of pathogens and resistance patterns in UTIs // J. Microbiol. and Infect. Dis. 1999. Vol. 28, № 1. P. 11‒14.

11. Acar J. F., Goldsein F. W. Trends in bacterial resistance to fl uoroquinolones // Clin. Infect. Dis. 1997. Vol. 24, № 1. P. 67‒73.

12. Azra S. H., Nair D., Kaur J., Baweja G. Resistance patterns of Urinary isolates in a tertiary Indian hospital // Ayub Med. Coll. Abottabad. 2007. Vol. 19. P. 39‒41.

13. Gupta K., Sahm D., Mayfi eld D., Stamm W. Antimicrobial resistance among uropathogens that cause community acquired UTIs in women : A nationwide analysis // Clin. Infect. Dis. 2001. Vol. 33. P. 89‒94.

14. Sleigh J. D., Timbury M. C. Notes on Medical Bacteriology. N.Y. : Churchill Livingstone Inc., 1986. P. 212‒218.

15. Kareem I. J., Raheed I. Y. Antibiotic susceptibilities of gram negative aerobic bacteria isolated from UTIs in community // Iraqi J. Med. Sci. 2011. Vol. 9, № 4. P. 295‒300.

16. Mahmood M. A. Prevalence and antimicrobial susceptibility of pathogens in UTIs // J. Al-Nahrain Univer. 2011. Vol. 14, № 4. P. 146‒152.

17. Bauer A. W., Kirby W. M., Sherris J. C., Truch M. Antibiotic susceptibility testing by standarized single disc method // Amer. J. Clin. Pathol. 1996. Vol. 45, № 4. P. 493‒496.

18. Karki A., Tiwari B. R., Pradhan S. B. Study on bacteria isolated from UTI and their sensitivity pattern // J. Nepal Med. Assoc. 2004. Vol. 43. P. 200‒203.

19. Adedeji B. A., Abdulkadir O. A. Etiology and antimicrobial resistance pattern of bacterial agents of UTIs in students of tertiary institusions in Yola metropolis // Advan. Biol. Res. 2009. Vol. 3, № 3‒4. P. 67‒70.

20. Mehr M. T., Khan H., Khan T. M., Iman N. U. Escherichia coliurine super bug and its antibiotic sensitivity: A perspective study // Med. Sci. 2010. Vol. 18, № 2. P. 110‒113.

21. Kebira A. N., Ochola P., Khamadi S. A. Isolation and antimicrobial susceptibility testing of Escherichia coli causing UTIs // Appl. Biosci. 2009. Vol. 22. P. 1320‒1325.

22. Atienza Morales M. P., Castellote Varona F. J., Romero Portilla C. UTI and antibiotic sensitivity in the south of Albacete, Spain // Anales de Medicina Interna. 1999. Vol. 16, № 5. P. 236‒238.

23. Ozumba U. C. Increasing incidence of bacterial resistance to antibiotics by isolates from the urinary tract, Niger // Intern. J. Clin. Prac. 2005. Vol. 8, № 2. P. 107‒109.

24. Muhammed A., Muhammed F., Muhammed A.-H., Imam H. A prospective study of patterns of UTIs and antibiotic sensitivity in rural setting of Mirpurkhas // Muhammed Med. Coll. 2010. Vol. 1, № 1. P. 10‒14.

25. Kiffer C. R., Kuti J. L., Eagye K. J., Mendes C., Nicolau D. P. Pharmacodynamic profi ling of imipenem, meropenem and ertapenem against clinical isolates of ESBL producing Escherichia coli and Klebsiella spp. from Brazil // Intern. J. Antimicrob. Agents. 2006. Vol. 28, № 4. P. 340‒344.

26. Rajesh K. R., Mathavi S., Priyadarsni R. I. Prevalence of antimicrobial resistance in uropathogens and determining empirical therapy for UTIs // Intern. J. Bas. and Appl. Med. Sci. 2010. Vol. 1, № 4. P. 210‒215.

27. Ahmed A. A., Osman H., Mansour A.M., Musa H. A. Antimicrobial agent resistance in bacterial isolates from patients with diarrhea and UTI in Sudan // Amer. J. Trop. Med. and Hyg. 2000. Vol. 63. P. 259‒263.

28. Ndugulile F., Jureen R., Harthug S., Urassa W., Langeland N. ESBLs among gram-negative bacteria of nosocomial origin from an intensive care unit of a tertiary health facility in Tanzania // BMC Infect. Dis. 2005. Vol. 5. P. 86.

29. Moyo S. J., Aboud S., Kasubi M., Lyamuya E. F., Maselle S. Y. Antimicrobial resistance among producers and non-producers of ESBLs in urinary isolates at a tertiary Hospital in Tanzania // BMC Res. Notes. 2010. Vol. 3. P. 348.

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